Obstructive sleep apnea, chronic obstructive pulmonary disease and NAFLD: an individual participant data meta-analysis
نویسندگان
چکیده
Chronic intermittent hypoxia occurring in obstructive sleep apnea (OSA) is independently associated with nonalcoholic fatty liver disease (NAFLD). pulmonary (COPD) has also been suggested to be linked disease. In this individual participant data meta-analysis, we investigated the association between damage and OSA COPD severity. Patients suspected of underwent polysomnography (PSG) or home testing (HSAT). Non-invasive tests were used evaluate steatosis (Hepatic Steatosis Index) fibrosis (Fibrotest FibroMeter). An meta-analysis approach was determine if severity OSA/COPD affects type Results confirmed by multivariate causal mediation analysis. Sub-group analyses performed investigate specific populations. Among 2120 patients, 1584 had (75%). multivariable analysis, risk factors for an apnea-hypopnea index (AHI) > 5/h, body mass (BMI) 26 kg/m2, age, 2 diabetes (all p-values <0.01) male gender (p = 0.02). Concerning fibrosis, among 2218 patients 397 (18%). Risk BMI>26 gender, <0.01). AHI not fibrosis. A combination >30/h stage 1 increased steatosis. This confirms strong OSA. The relation mainly due BMI as shown
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ژورنال
عنوان ژورنال: Sleep Medicine
سال: 2021
ISSN: ['1389-9457', '1878-5506']
DOI: https://doi.org/10.1016/j.sleep.2020.04.004